About Ras-related protein Rab-18
Ras-related protein Rab-18 (RAB18) is a protein
from Homo sapiens identified by UniProt accession
Q9NP72, 206 residues long.
MolForge cross-references it against 0 known binders and
158 disease associations.
Target properties
| Protein name | Ras-related protein Rab-18 |
|---|
| UniProt accession | Q9NP72 |
|---|
| Gene | RAB18 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 206 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (158)
Diseases linked to this target (Open Targets).
- Micro syndrome · score 0.80
- Warburg micro syndrome · score 0.53
- neurodegenerative disease · score 0.50
- heel bone mineral density · score 0.35
- body height · score 0.33
- bone quantitative ultrasound measurement · score 0.32
- BMI-adjusted waist circumference · score 0.31
- lean body mass · score 0.30
- appendicular lean mass · score 0.28
- BMI-adjusted waist-hip ratio · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NP72-F1 | alphafold | PREDICTED | 85.56 | — |
Amino-acid sequence (206 residues)
MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI SVDGNKAKLA IWDTAGQERF RTLTPSYYRG AQGVILVYDV TRRDTFVKLD NWLNELETYC TRNDIVNMLV GNKIDKENRE VDRNEGLKFA RKHSMLFIEA SAKTCDGVQC AFEELVEKII QTPGLWESEN QNKGVKLSHR EEGQGGGACG GYCSVL
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