RNA polymerase II subunit A C-terminal domain…

About RNA polymerase II subunit A C-terminal domain phosphatase SSU72

RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (SSU72) is a protein from Homo sapiens identified by UniProt accession Q9NP77, 194 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	RNA polymerase II subunit A C-terminal domain phosphatase SSU72
UniProt accession	Q9NP77
Gene	SSU72
Organism	Homo sapiens
Length	194 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
sex hormone-binding globulin measurement · score 0.23
serum albumin measurement · score 0.20
alkaline phosphatase measurement · score 0.16
IGF-1 measurement · score 0.15
major depressive disorder · score 0.06
rheumatoid arthritis · score 0.05
hepatocellular carcinoma · score 0.02
inflammatory bowel disease · score 0.01
non-alcoholic fatty liver disease · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NP77-F1	alphafold	PREDICTED	95.70	—

Amino-acid sequence (194 residues)

MPSSPLRVAV VCSSNQNRSM EAHNILSKRG FSVRSFGTGT HVKLPGPAPD KPNVYDFKTT YDQMYNDLLR KDKELYTQNG ILHMLDRNKR IKPRPERFQN CKDLFDLILT CEERVYDQVV EDLNSREQET CQPVHVVNVD IQDNHEEATL GAFLICELCQ CIQHTEDMEN EIDELLQEFE EKSGRTFLHT VCFY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (SSU72)