About Calcium-independent phospholipase A2-gamma
Calcium-independent phospholipase A2-gamma (PNPLA8) is a protein
from Homo sapiens identified by UniProt accession
Q9NP80, 782 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | Calcium-independent phospholipase A2-gamma |
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| UniProt accession | Q9NP80 |
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| Gene | PNPLA8 |
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| Organism | Homo sapiens |
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| Length | 782 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (74)
Diseases linked to this target (Open Targets).
- mitochondrial myopathy-lactic acidosis-deafness syndrome · score 0.62
- Mitochondrial myopathy - lactic acidosis - deafness · score 0.62
- genetic disorder · score 0.34
- self reported educational attainment · score 0.33
- alkaline phosphatase measurement · score 0.29
- Abnormality of the musculature · score 0.27
- protein measurement · score 0.22
- Lynch syndrome · score 0.18
- mismatch repair cancer syndrome · score 0.18
- breast adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NP80-F1 | alphafold | PREDICTED | 66.86 | — |
Amino-acid sequence (782 residues)
MSINLTVDIY IYLLSNARSV CGKQRSKQLY FLFSPKHYWR ISHISLQRGF HTNIIRCKWT KSEAHSCSKH CYSPSNHGLH IGILKLSTSA PKGLTKVNIC MSRIKSTLNS VSKAVFGNQN EMISRLAQFK PSSQILRKVS DSGWLKQKNI KQAIKSLKKY SDKSAEKSPF PEEKSHIIDK EEDIGKRSLF HYTSSITTKF GDSFYFLSNH INSYFKRKEK MSQQKENEHF RDKSELEDKK VEEGKLRSPD PGILAYKPGS ESVHTVDKPT SPSAIPDVLQ VSTKQSIANF LSRPTEGVQA LVGGYIGGLV PKLKYDSKSQ SEEQEEPAKT DQAVSKDRNA EEKKRLSLQR EKIIARVSID NRTRALVQAL RRTTDPKLCI TRVEELTFHL LEFPEGKGVA VKERIIPYLL RLRQIKDETL QAAVREILAL IGYVDPVKGR GIRILSIDGG GTRGVVALQT LRKLVELTQK PVHQLFDYIC GVSTGAILAF MLGLFHMPLD ECEELYRKLG SDVFSQNVIV GTVKMSWSHA FYDSQTWENI LKDRMGSALM IETARNPTCP KVAAVSTIVN RGITPKAFVF RNYGHFPGIN SHYLGGCQYK MWQAIRASSA APGYFAEYAL GNDLHQDGGL LLNNPSALAM HECKCLWPDV PLECIVSLGT GRYESDVRNT VTYTSLKTKL SNVINSATDT EEVHIMLDGL LPPDTYFRFN PVMCENIPLD ESRNEKLDQL QLEGLKYIER NEQKMKKVAK ILSQEKTTLQ KINDWIKLKT DMYEGLPFFS KL
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