About Serine--tRNA ligase, mitochondrial
Serine--tRNA ligase, mitochondrial (SARS2) is a protein
from Homo sapiens identified by UniProt accession
Q9NP81, 518 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | Serine--tRNA ligase, mitochondrial |
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| UniProt accession | Q9NP81 |
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| Gene | SARS2 |
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| Organism | Homo sapiens |
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| Length | 518 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (48)
Diseases linked to this target (Open Targets).
- hyperuricemia-pulmonary hypertension-renal failure-alkalosis syndrome · score 0.78
- body height · score 0.21
- mitochondrial disease · score 0.19
- serum gamma-glutamyl transferase measurement · score 0.18
- diastolic blood pressure · score 0.13
- SIR2-like protein 2 measurement · score 0.05
- fat body mass · score 0.04
- COVID-19 · score 0.03
- infection · score 0.03
- infect · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NP81-F1 | alphafold | PREDICTED | 90.49 | — |
Amino-acid sequence (518 residues)
MAASMARRLW PLLTRRGFRP RGGCISNDSP RRSFTTEKRN RNLLYEYARE GYSALPQLDI ERFCACPEEA AHALELRKGE LRSADLPAII STWQELRQLQ EQIRSLEEEK AAVTEAVRAL LANQDSGEVQ QDPKYQGLRA RGREIRKELV HLYPREAQLE EQFYLQALKL PNQTHPDVPV GDESQARVLH MVGDKPVFSF QPRGHLEIGE KLDIIRQKRL SHVSGHRSYY LRGAGALLQH GLVNFTFNKL LRRGFTPMTV PDLLRGAVFE GCGMTPNANP SQIYNIDPAR FKDLNLAGTA EVGLAGYFMD HTVAFRDLPV RMVCSSTCYR AETNTGQEPR GLYRVHHFTK VEMFGVTGPG LEQSSQLLEE FLSLQMEILT ELGLHFRVLD MPTQELGLPA YRKFDIEAWM PGRGRFGEVT SASNCTDFQS RRLHIMFQTE AGELQFAHTV NATACAVPRL LIALLESNQQ KDGSVLVPPA LQSYLGTDRI TAPTHVPLQY IGPNQPRKPG LPGQPAVS
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