Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)

About Tumor necrosis factor receptor superfamily member 12A

Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) is a protein from Homo sapiens identified by UniProt accession Q9NP84, 129 residues long. MolForge cross-references it against 0 known binders and 295 disease associations.

Target properties

Protein name	Tumor necrosis factor receptor superfamily member 12A
UniProt accession	Q9NP84
Gene	TNFRSF12A
Organism	Homo sapiens
Length	129 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (295)

Diseases linked to this target (Open Targets).

neoplasm · score 0.11
glioblastoma multiforme · score 0.10
hepatocellular carcinoma · score 0.10
breast cancer · score 0.09
triple-negative breast cancer · score 0.08
melanoma · score 0.08
acute kidney failure · score 0.08
acute lung injury · score 0.08
Pallister-Hall syndrome · score 0.08
Cholestasis · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NP84-F1	alphafold	PREDICTED	73.22	—

Amino-acid sequence (129 residues)

MARGSLRRLL RLLVLGLWLA LLRSVAGEQA PGTAPCSRGS SWSADLDKCM DCASCRARPH SDFCLGCAAA PPAPFRLLWP ILGGALSLTF VLGLLSGFLV WRRCRRREKF TTPIEETGGE GCPAVALIQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards