About Podocin
Podocin (NPHS2) is a protein
from Homo sapiens identified by UniProt accession
Q9NP85, 383 residues long.
MolForge cross-references it against 0 known binders and
247 disease associations.
Target properties
| Protein name | Podocin |
|---|
| UniProt accession | Q9NP85 |
|---|
| Gene | NPHS2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 383 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (247)
Diseases linked to this target (Open Targets).
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.78
- nephrotic syndrome · score 0.60
- steroid-resistant nephrotic syndrome · score 0.54
- idiopathic nephrotic syndrome · score 0.51
- trait in response to prednisolone · score 0.50
- focal segmental glomerulosclerosis · score 0.49
- genetic disorder · score 0.48
- congenital nephrotic syndrome, Finnish type · score 0.39
- Proteinuria · score 0.38
- diastolic blood pressure · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NP85-F1 | alphafold | PREDICTED | 74.16 | — |
Amino-acid sequence (383 residues)
MERRARSSSR ESRGRGGRTP HKENKRAKAE RSGGGRGRQE AGPEPSGSGR AGTPGEPRAP AATVVDVDEV RGSGEEGTEV VALLESERPE EGTKSSGLGA CEWLLVLISL LFIIMTFPFS IWFCVKVVQE YERVIIFRLG HLLPGRAKGP GLFFFLPCLD TYHKVDLRLQ TLEIPFHEIV TKDMFIMEID AICYYRMENA SLLLSSLAHV SKAVQFLVQT TMKRLLAHRS LTEILLERKS IAQDAKVALD SVTCIWGIKV ERIEIKDVRL PAGLQHSLAV EAEAQRQAKV RMIAAEAEKA ASESLRMAAE ILSGTPAAVQ LRYLHTLQSL STEKPSTVVL PLPFDLLNCL SSPSNRTQGS LPFPSPSKPV EPLNPKKKDS PML
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