DNA-directed DNA/RNA polymerase mu (POLM)

About DNA-directed DNA/RNA polymerase mu

DNA-directed DNA/RNA polymerase mu (POLM) is a protein from Homo sapiens identified by UniProt accession Q9NP87, 494 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.

Target properties

Protein name	DNA-directed DNA/RNA polymerase mu
UniProt accession	Q9NP87
Gene	POLM
Organism	Homo sapiens
Length	494 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (79)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.31
breast adenocarcinoma · score 0.23
ovarian cancer · score 0.18
lung adenocarcinoma · score 0.12
mean platelet volume · score 0.10
clear cell renal carcinoma · score 0.10
esophageal cancer · score 0.09
reticulocyte count · score 0.09
neutropenia, severe congenital, 2, autosomal dominant · score 0.07
Okt4 epitope deficiency · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NP87-F1	alphafold	PREDICTED	88.56	—

Amino-acid sequence (494 residues)

MLPKRRRARV GSPSGDAASS TPPSTRFPGV AIYLVEPRMG RSRRAFLTGL ARSKGFRVLD ACSSEATHVV MEETSAEEAV SWQERRMAAA PPGCTPPALL DISWLTESLG AGQPVPVECR HRLEVAGPRK GPLSPAWMPA YACQRPTPLT HHNTGLSEAL EILAEAAGFE GSEGRLLTFC RAASVLKALP SPVTTLSQLQ GLPHFGEHSS RVVQELLEHG VCEEVERVRR SERYQTMKLF TQIFGVGVKT ADRWYREGLR TLDDLREQPQ KLTQQQKAGL QHHQDLSTPV LRSDVDALQQ VVEEAVGQAL PGATVTLTGG FRRGKLQGHD VDFLITHPKE GQEAGLLPRV MCRLQDQGLI LYHQHQHSCC ESPTRLAQQS HMDAFERSFC IFRLPQPPGA AVGGSTRPCP SWKAVRVDLV VAPVSQFPFA LLGWTGSKLF QRELRRFSRK EKGLWLNSHG LFDPEQKTFF QAASEEDIFR HLGLEYLPPE QRNA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards