About Triggering receptor expressed on myeloid cells 1
Triggering receptor expressed on myeloid cells 1 (TREM1) is a protein
from Homo sapiens identified by UniProt accession
Q9NP99, 234 residues long.
MolForge cross-references it against 0 known binders and
430 disease associations.
Target properties
| Protein name | Triggering receptor expressed on myeloid cells 1 |
|---|
| UniProt accession | Q9NP99 |
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| Gene | TREM1 |
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| Organism | Homo sapiens |
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| Length | 234 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (430)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.38
- bone density · score 0.32
- urate measurement · score 0.32
- neurodegenerative disease · score 0.24
- glioblastoma multiforme · score 0.21
- breast adenocarcinoma · score 0.18
- neoplasm · score 0.12
- head and neck squamous cell carcinoma · score 0.11
- Sepsis · score 0.11
- Rheumatoid arthritis · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NP99-F1 | alphafold | PREDICTED | 71.59 | — |
Amino-acid sequence (234 residues)
MRKTRLWGLL WMLFVSELRA ATKLTEEKYE LKEGQTLDVK CDYTLEKFAS SQKAWQIIRD GEMPKTLACT ERPSKNSHPV QVGRIILEDY HDHGLLRVRM VNLQVEDSGL YQCVIYQPPK EPHMLFDRIR LVVTKGFSGT PGSNENSTQN VYKIPPTTTK ALCPLYTSPR TVTQAPPKST ADVSTPDSEI NLTNVTDIIR VPVFNIVILL AGGFLSKSLV FSVLFAVTLR SFVP
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