Matrix metalloproteinase-25 (MMP25)

About Matrix metalloproteinase-25

Matrix metalloproteinase-25 (MMP25) is a protein from Homo sapiens identified by UniProt accession Q9NPA2, 562 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	Matrix metalloproteinase-25
UniProt accession	Q9NPA2
Gene	MMP25
Organism	Homo sapiens
Length	562 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.43
multiple sclerosis · score 0.41
lysosomal storage disease · score 0.41
Parkinson disease · score 0.41
Alzheimer disease · score 0.41
neuroinflammatory disorder · score 0.27
breast adenocarcinoma · score 0.22
drug use measurement · score 0.17
lung adenocarcinoma · score 0.17
aspartate aminotransferase measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NPA2-F1	alphafold	PREDICTED	78.16	—

Amino-acid sequence (562 residues)

MRLRLRLLAL LLLLLAPPAR APKPSAQDVS LGVDWLTRYG YLPPPHPAQA QLQSPEKLRD AIKVMQRFAG LPETGRMDPG TVATMRKPRC SLPDVLGVAG LVRRRRRYAL SGSVWKKRTL TWRVRSFPQS SQLSQETVRV LMSYALMAWG MESGLTFHEV DSPQGQEPDI LIDFARAFHQ DSYPFDGLGG TLAHAFFPGE HPISGDTHFD DEETWTFGSK DGEGTDLFAV AVHEFGHALG LGHSSAPNSI MRPFYQGPVG DPDKYRLSQD DRDGLQQLYG KAPQTPYDKP TRKPLAPPPQ PPASPTHSPS FPIPDRCEGN FDAIANIRGE TFFFKGPWFW RLQPSGQLVS PRPARLHRFW EGLPAQVRVV QAAYARHRDG RILLFSGPQF WVFQDRQLEG GARPLTELGL PPGEEVDAVF SWPQNGKTYL VRGRQYWRYD EAAARPDPGY PRDLSLWEGA PPSPDDVTVS NAGDTYFFKG AHYWRFPKNS IKTEPDAPQP MGPNWLDCPA PSSGPRAPRP PKATPVSETC DCQCELNQAA GRWPAPIPLL LLPLLVGGVA SR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards