About 5'(3')-deoxyribonucleotidase, mitochondrial
5'(3')-deoxyribonucleotidase, mitochondrial (NT5M) is a protein
from Homo sapiens identified by UniProt accession
Q9NPB1, 228 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | 5'(3')-deoxyribonucleotidase, mitochondrial |
|---|
| UniProt accession | Q9NPB1 |
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| Gene | NT5M |
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| Organism | Homo sapiens |
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| Length | 228 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.23
- cutaneous melanoma · score 0.22
- neuroinflammatory disorder · score 0.17
- heel bone mineral density · score 0.08
- reticulocyte count · score 0.06
- mean corpuscular volume · score 0.06
- glucose measurement · score 0.05
- neutrophil percentage of leukocytes · score 0.05
- coronary artery disease · score 0.04
- neutrophil count · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NPB1-F1 | alphafold | PREDICTED | 89.88 | — |
Amino-acid sequence (228 residues)
MIRLGGWCAR RLCSAAVPAG RRGAAGGLGL AGGRALRVLV DMDGVLADFE GGFLRKFRAR FPDQPFIALE DRRGFWVSEQ YGRLRPGLSE KAISIWESKN FFFELEPLPG AVEAVKEMAS LQNTDVFICT SPIKMFKYCP YEKYAWVEKY FGPDFLEQIV LTRDKTVVSA DLLIDDRPDI TGAEPTPSWE HVLFTACHNQ HLQLQPPRRR LHSWADDWKA ILDSKRPC
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