Partitioning defective 6 homolog alpha (PARD6A)

About Partitioning defective 6 homolog alpha

Partitioning defective 6 homolog alpha (PARD6A) is a protein from Homo sapiens identified by UniProt accession Q9NPB6, 346 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.

Target properties

Protein name	Partitioning defective 6 homolog alpha
UniProt accession	Q9NPB6
Gene	PARD6A
Organism	Homo sapiens
Length	346 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (68)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.29
mean corpuscular hemoglobin · score 0.20
MODY · score 0.11
mean reticulocyte volume · score 0.10
type 2 diabetes mellitus · score 0.08
Myopia · score 0.07
age at onset · score 0.07
type 1 diabetes mellitus · score 0.07
diabetes mellitus, transient neonatal, 2 · score 0.07
mean corpuscular hemoglobin concentration · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NPB6-F1	alphafold	PREDICTED	73.49	—

Amino-acid sequence (346 residues)

MARPQRTPAR SPDSIVEVKS KFDAEFRRFA LPRASVSGFQ EFSRLLRAVH QIPGLDVLLG YTDAHGDLLP LTNDDSLHRA LASGPPPLRL LVQKRAEADS SGLAFASNSL QRRKKGLLLR PVAPLRTRPP LLISLPQDFR QVSSVIDVDL LPETHRRVRL HKHGSDRPLG FYIRDGMSVR VAPQGLERVP GIFISRLVRG GLAESTGLLA VSDEILEVNG IEVAGKTLDQ VTDMMVANSH NLIVTVKPAN QRNNVVRGAS GRLTGPPSAG PGPAEPDSDD DSSDLVIENR QPPSSNGLSQ GPPCWDLHPG CRHPGTRSSL PSLDDQEQAS SGWGSRIRGD GSGFSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards