About Glycerophosphocholine phosphodiesterase GPCPD1
Glycerophosphocholine phosphodiesterase GPCPD1 (GPCPD1) is a protein
from Homo sapiens identified by UniProt accession
Q9NPB8, 672 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | Glycerophosphocholine phosphodiesterase GPCPD1 |
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| UniProt accession | Q9NPB8 |
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| Gene | GPCPD1 |
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| Organism | Homo sapiens |
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| Length | 672 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (43)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.44
- calcium measurement · score 0.42
- BMI-adjusted waist-hip ratio · score 0.37
- BMI-adjusted hip circumference · score 0.34
- heel bone mineral density · score 0.34
- alkaline phosphatase measurement · score 0.34
- waist-hip ratio · score 0.33
- optic cup area measurement · score 0.32
- BMI-adjusted waist circumference · score 0.31
- total cholesterol measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NPB8-F1 | alphafold | PREDICTED | 87.13 | — |
Amino-acid sequence (672 residues)
MTPSQVAFEI RGTLLPGEVF AICGSCDALG NWNPQNAVAL LPENDTGESM LWKATIVLSR GVSVQYRYFK GYFLEPKTIG GPCQVIVHKW ETHLQPRSIT PLESEIIIDD GQFGIHNGVE TLDSGWLTCQ TEIRLRLHYS EKPPVSITKK KLKKSRFRVK LTLEGLEEDD DDRVSPTVLH KMSNSLEISL ISDNEFKCRH SQPECGYGLQ PDRWTEYSIQ TMEPDNLELI FDFFEEDLSE HVVQGDALPG HVGTACLLSS TIAESGKSAG ILTLPIMSRN SRKTIGKVRV DYIIIKPLPG YSCDMKSSFS KYWKPRIPLD VGHRGAGNST TTAQLAKVQE NTIASLRNAA SHGAAFVEFD VHLSKDFVPV VYHDLTCCLT MKKKFDADPV ELFEIPVKEL TFDQLQLLKL THVTALKSKD RKESVVQEEN SFSENQPFPS LKMVLESLPE DVGFNIEIKW ICQQRDGMWD GNLSTYFDMN LFLDIILKTV LENSGKRRIV FSSFDADICT MVRQKQNKYP ILFLTQGKSE IYPELMDLRS RTTPIAMSFA QFENLLGINV HTEDLLRNPS YIQEAKAKGL VIFCWGDDTN DPENRRKLKE LGVNGLIYDR IYDWMPEQPN IFQVEQLERL KQELPELKSC LCPTVSRFVP SSLCGESDIH VDANGIDNVE NA
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