Leukotriene B4 receptor 2 (LTB4R2)

About Leukotriene B4 receptor 2

Leukotriene B4 receptor 2 (LTB4R2) is a protein from Homo sapiens identified by UniProt accession Q9NPC1, 358 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.

Target properties

Protein name	Leukotriene B4 receptor 2
UniProt accession	Q9NPC1
Gene	LTB4R2
Organism	Homo sapiens
Length	358 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (97)

Diseases linked to this target (Open Targets).

paroxysmal nocturnal hemoglobinuria · score 0.28
bullous pemphigoid · score 0.26
breast adenocarcinoma · score 0.24
thyroid gland adenocarcinoma · score 0.23
language impairment · score 0.13
hepatocellular carcinoma · score 0.07
rheumatoid arthritis · score 0.07
Sepsis · score 0.07
osteoarthritis · score 0.07
chondrocalcinosis 2 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NPC1-F1	alphafold	PREDICTED	81.10	—

Amino-acid sequence (358 residues)

MSVCYRPPGN ETLLSWKTSR ATGTAFLLLA ALLGLPGNGF VVWSLAGWRP ARGRPLAATL VLHLALADGA VLLLTPLFVA FLTRQAWPLG QAGCKAVYYV CALSMYASVL LTGLLSLQRC LAVTRPFLAP RLRSPALARR LLLAVWLAAL LLAVPAAVYR HLWRDRVCQL CHPSPVHAAA HLSLETLTAF VLPFGLMLGC YSVTLARLRG ARWGSGRHGA RVGRLVSAIV LAFGLLWAPY HAVNLLQAVA ALAPPEGALA KLGGAGQAAR AGTTALAFFS SSVNPVLYVF TAGDLLPRAG PRFLTRLFEG SGEARGGGRS REGTMELRTT PQLKVVGQGR GNGDPGGGME KDGPEWDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards