Lactosylceramide 4-alpha-galactosyltransferase (A4GALT)

About Lactosylceramide 4-alpha-galactosyltransferase

Lactosylceramide 4-alpha-galactosyltransferase (A4GALT) is a protein from Homo sapiens identified by UniProt accession Q9NPC4, 353 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	Lactosylceramide 4-alpha-galactosyltransferase
UniProt accession	Q9NPC4
Gene	A4GALT
Organism	Homo sapiens
Length	353 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NPC4-F1	alphafold	PREDICTED	89.26	—

Amino-acid sequence (353 residues)

MSKPPDLLLR LLRGAPRQRV CTLFIIGFKF TFFVSIMIYW HVVGEPKEKG QLYNLPAEIP CPTLTPPTPP SHGPTPGNIF FLETSDRTNP NFLFMCSVES AARTHPESHV LVLMKGLPGG NASLPRHLGI SLLSCFPNVQ MLPLDLRELF RDTPLADWYA AVQGRWEPYL LPVLSDASRI ALMWKFGGIY LDTDFIVLKN LRNLTNVLGT QSRYVLNGAF LAFERRHEFM ALCMRDFVDH YNGWIWGHQG PQLLTRVFKK WCSIRSLAES RACRGVTTLP PEAFYPIPWQ DWKKYFEDIN PEELPRLLSA TYAVHVWNKK SQGTRFEATS RALLAQLHAR YCPTTHEAMK MYL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards