About Homeobox protein SIX2
Homeobox protein SIX2 (SIX2) is a protein
from Homo sapiens identified by UniProt accession
Q9NPC8, 291 residues long.
MolForge cross-references it against 0 known binders and
223 disease associations.
Target properties
| Protein name | Homeobox protein SIX2 |
|---|
| UniProt accession | Q9NPC8 |
|---|
| Gene | SIX2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 291 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (223)
Diseases linked to this target (Open Targets).
- facial morphology measurement · score 0.35
- nose morphology measurement · score 0.34
- heel bone mineral density · score 0.33
- lip morphology measurement · score 0.27
- brain measurement · score 0.21
- cortical thickness · score 0.20
- cortical surface area measurement · score 0.20
- hepatocellular carcinoma · score 0.19
- lung adenocarcinoma · score 0.19
- colon adenocarcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NPC8-F1 | alphafold | PREDICTED | 74.15 | — |
Amino-acid sequence (291 residues)
MSMLPTFGFT QEQVACVCEV LQQGGNIERL GRFLWSLPAC EHLHKNESVL KAKAVVAFHR GNFRELYKIL ESHQFSPHNH AKLQQLWLKA HYIEAEKLRG RPLGAVGKYR VRRKFPLPRS IWDGEETSYC FKEKSRSVLR EWYAHNPYPS PREKRELAEA TGLTTTQVSN WFKNRRQRDR AAEAKERENN ENSNSNSHNP LNGSGKSVLG SSEDEKTPSG TPDHSSSSPA LLLSPPPPGL PSLHSLGHPP GPSAVPVPVP GGGGADPLQH HHGLQDSILN PMSANLVDLG S
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