About Solute carrier organic anion transporter family member 1B3
Solute carrier organic anion transporter family member 1B3 (SLCO1B3) is a protein
from Homo sapiens identified by UniProt accession
Q9NPD5, 702 residues long.
MolForge cross-references it against 0 known binders and
209 disease associations.
Target properties
| Protein name | Solute carrier organic anion transporter family member 1B3 |
|---|
| UniProt accession | Q9NPD5 |
|---|
| Gene | SLCO1B3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 702 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (209)
Diseases linked to this target (Open Targets).
- bilirubin measurement · score 0.72
- Rotor syndrome · score 0.65
- sex hormone-binding globulin measurement · score 0.52
- serum alanine aminotransferase measurement · score 0.46
- serum gamma-glutamyl transferase measurement · score 0.41
- aspartate aminotransferase measurement · score 0.41
- Disorder of bilirubin metabolism and excretion · score 0.37
- ceramide measurement · score 0.31
- platelet count · score 0.24
- cutaneous melanoma · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NPD5-F1 | alphafold | PREDICTED | 79.09 | — |
Amino-acid sequence (702 residues)
MDQHQHLNKT AESASSEKKK TRRCNGFKMF LAALSFSYIA KALGGIIMKI SITQIERRFD ISSSLAGLID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG CLLMGTGSIL TSLPHFFMGY YRYSKETHIN PSENSTSSLS TCLINQTLSF NGTSPEIVEK DCVKESGSHM WIYVFMGNML RGIGETPIVP LGISYIDDFA KEGHSSLYLG SLNAIGMIGP VIGFALGSLF AKMYVDIGYV DLSTIRITPK DSRWVGAWWL GFLVSGLFSI ISSIPFFFLP KNPNKPQKER KISLSLHVLK TNDDRNQTAN LTNQGKNVTK NVTGFFQSLK SILTNPLYVI FLLLTLLQVS SFIGSFTYVF KYMEQQYGQS ASHANFLLGI ITIPTVATGM FLGGFIIKKF KLSLVGIAKF SFLTSMISFL FQLLYFPLIC ESKSVAGLTL TYDGNNSVAS HVDVPLSYCN SECNCDESQW EPVCGNNGIT YLSPCLAGCK SSSGIKKHTV FYNCSCVEVT GLQNRNYSAH LGECPRDNTC TRKFFIYVAI QVINSLFSAT GGTTFILLTV KIVQPELKAL AMGFQSMVIR TLGGILAPIY FGALIDKTCM KWSTNSCGAQ GACRIYNSVF FGRVYLGLSI ALRFPALVLY IVFIFAMKKK FQGKDTKASD NERKVMDEAN LEFLNNGEHF VPSAGTDSKT CNLDMQDNAA AN
Explore Solute carrier organic anion transporter family member 1B3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets