Ubiquitin-conjugating enzyme E2 T (UBE2T)

About Ubiquitin-conjugating enzyme E2 T

Ubiquitin-conjugating enzyme E2 T (UBE2T) is a protein from Homo sapiens identified by UniProt accession Q9NPD8, 197 residues long. MolForge cross-references it against 0 known binders and 121 disease associations.

Target properties

Protein name	Ubiquitin-conjugating enzyme E2 T
UniProt accession	Q9NPD8
Gene	UBE2T
Organism	Homo sapiens
Length	197 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (121)

Diseases linked to this target (Open Targets).

Fanconi anemia · score 0.65
myelodysplastic syndrome · score 0.48
acute myeloid leukemia · score 0.46
breast adenocarcinoma · score 0.18
hepatocellular carcinoma · score 0.12
lung adenocarcinoma · score 0.11
bilirubin measurement · score 0.11
glioblastoma multiforme · score 0.10
acne · score 0.10
brain measurement · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NPD8-F1	alphafold	PREDICTED	86.27	—

Amino-acid sequence (197 residues)

MQRASRLKRE LHMLATEPPP GITCWQDKDQ MDDLRAQILG GANTPYEKGV FKLEVIIPER YPFEPPQIRF LTPIYHPNID SAGRICLDVL KLPPKGAWRP SLNIATVLTS IQLLMSEPNP DDPLMADISS EFKYNKPAFL KNARQWTEKH ARQKQKADEE EMLDNLPEAG DSRVHNSTQK RKASQLVGIE KKFHPDV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards