DNA methyltransferase 1-associated protein 1 (DMAP1)

About DNA methyltransferase 1-associated protein 1

DNA methyltransferase 1-associated protein 1 (DMAP1) is a protein from Homo sapiens identified by UniProt accession Q9NPF5, 467 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	DNA methyltransferase 1-associated protein 1
UniProt accession	Q9NPF5
Gene	DMAP1
Organism	Homo sapiens
Length	467 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
Intellectual disability · score 0.30
Abnormal facial shape · score 0.30
Seizure · score 0.30
self reported educational attainment · score 0.12
diet measurement · score 0.12
Generalized hypotonia · score 0.11
Profound global developmental delay · score 0.11
breast cancer · score 0.07
mathematical ability · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NPF5-F1	alphafold	PREDICTED	73.72	—

Amino-acid sequence (467 residues)

MATGADVRDI LELGGPEGDA ASGTISKKDI INPDKKKSKK SSETLTFKRP EGMHREVYAL LYSDKKDAPP LLPSDTGQGY RTVKAKLGSK KVRPWKWMPF TNPARKDGAM FFHWRRAAEE GKDYPFARFN KTVQVPVYSE QEYQLYLHDD AWTKAETDHL FDLSRRFDLR FVVIHDRYDH QQFKKRSVED LKERYYHICA KLANVRAVPG TDLKIPVFDA GHERRRKEQL ERLYNRTPEQ VAEEEYLLQE LRKIEARKKE REKRSQDLQK LITAADTTAE QRRTERKAPK KKLPQKKEAE KPAVPETAGI KFPDFKSAGV TLRSQRMKLP SSVGQKKIKA LEQMLLELGV ELSPTPTEEL VHMFNELRSD LVLLYELKQA CANCEYELQM LRHRHEALAR AGVLGGPATP ASGPGPASAE PAVTEPGLGP DPKDTIIDVV GAPLTPNSRK RRESASSSSS VKKAKKP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards