About Arf-GAP with dual PH domain-containing protein 2
Arf-GAP with dual PH domain-containing protein 2 (ADAP2) is a protein
from Homo sapiens identified by UniProt accession
Q9NPF8, 381 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | Arf-GAP with dual PH domain-containing protein 2 |
|---|
| UniProt accession | Q9NPF8 |
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| Gene | ADAP2 |
|---|
| Organism | Homo sapiens |
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| Length | 381 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (77)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.45
- body height · score 0.43
- BMI-adjusted waist circumference · score 0.37
- mean corpuscular hemoglobin · score 0.34
- diastolic blood pressure · score 0.30
- vital capacity · score 0.28
- mitochondrial DNA measurement · score 0.28
- breast carcinoma · score 0.20
- BMI-adjusted hip circumference · score 0.20
- lean body mass · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NPF8-F1 | alphafold | PREDICTED | 92.11 | — |
Amino-acid sequence (381 residues)
MGDRERNKKR LLELLRAPDT GNAHCADCGA ADPDWASYKL GIFICLNCCG VHRNFPDISR VKSVRLDFWD DSIVEFMIHN GNLRVKAKFE ARVPAFYYIP QANDCLVLKE QWIRAKYERR EFMADGETIS LPGNREGFLW KRGRDNSQFL RRKFVLLARE GLLKYFTKEQ GKSPKAVISI KDLNATFQTE KIGHPHGLQI TYRRDGHTRN LFVYHESGKE IVDWFNALRA ARLQYLKMAF PELPESELVP FLTRNYLKQG FMEKTGPKQK EPFKKRWFAL DCHERRLLYY KNPLDAFEQG QVFLGNKEQG YEAYEDLPKG IRGNRWKAGL TIVTPERRFV LTCPSEKEQQ EWLESLRGVL SSPLTPLNRL TASTESGRSS R
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