Lysophosphatidic acid phosphatase type 6 (ACP6)

About Lysophosphatidic acid phosphatase type 6

Lysophosphatidic acid phosphatase type 6 (ACP6) is a protein from Homo sapiens identified by UniProt accession Q9NPH0, 428 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.

Target properties

Protein name	Lysophosphatidic acid phosphatase type 6
UniProt accession	Q9NPH0
Gene	ACP6
Organism	Homo sapiens
Length	428 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (85)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.36
body height · score 0.34
Rare genetic intellectual disability with developmental anomaly · score 0.27
glioblastoma multiforme · score 0.18
breast adenocarcinoma · score 0.18
granulocyte count · score 0.16
hepatocellular carcinoma · score 0.07
response to fenofibrate · score 0.07
triglyceride change measurement · score 0.07
response to simvastatin · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NPH0-F1	alphafold	PREDICTED	90.90	—

Amino-acid sequence (428 residues)

MITGVFSMRL WTPVGVLTSL AYCLHQRRVA LAELQEADGQ CPVDRSLLKL KMVQVVFRHG ARSPLKPLPL EEQVEWNPQL LEVPPQTQFD YTVTNLAGGP KPYSPYDSQY HETTLKGGMF AGQLTKVGMQ QMFALGERLR KNYVEDIPFL SPTFNPQEVF IRSTNIFRNL ESTRCLLAGL FQCQKEGPII IHTDEADSEV LYPNYQSCWS LRQRTRGRRQ TASLQPGISE DLKKVKDRMG IDSSDKVDFF ILLDNVAAEQ AHNLPSCPML KRFARMIEQR AVDTSLYILP KEDRESLQMA VGPFLHILES NLLKAMDSAT APDKIRKLYL YAAHDVTFIP LLMTLGIFDH KWPPFAVDLT MELYQHLESK EWFVQLYYHG KEQVPRGCPD GLCPLDMFLN AMSVYTLSPE KYHALCSQTQ VMEVGNEE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards