About Inositol-3-phosphate synthase 1
Inositol-3-phosphate synthase 1 (ISYNA1) is a protein
from Homo sapiens identified by UniProt accession
Q9NPH2, 558 residues long.
MolForge cross-references it against 0 known binders and
102 disease associations.
Target properties
| Protein name | Inositol-3-phosphate synthase 1 |
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| UniProt accession | Q9NPH2 |
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| Gene | ISYNA1 |
|---|
| Organism | Homo sapiens |
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| Length | 558 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (102)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- heel bone mineral density · score 0.30
- body height · score 0.28
- breast carcinoma · score 0.19
- total blood protein measurement · score 0.18
- mean corpuscular hemoglobin concentration · score 0.18
- monocyte count · score 0.18
- erythrocyte count · score 0.17
- smoking status measurement · score 0.16
- basophil count · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NPH2-F1 | alphafold | PREDICTED | 91.80 | — |
Amino-acid sequence (558 residues)
MEAAAQFFVE SPDVVYGPEA IEAQYEYRTT RVSREGGVLK VHPTSTRFTF RTARQVPRLG VMLVGWGGNN GSTLTAAVLA NRLRLSWPTR SGRKEANYYG SLTQAGTVSL GLDAEGQEVF VPFSAVLPMV APNDLVFDGW DISSLNLAEA MRRAKVLDWG LQEQLWPHME ALRPRPSVYI PEFIAANQSA RADNLIPGSR AQQLEQIRRD IRDFRSSAGL DKVIVLWTAN TERFCEVIPG LNDTAENLLR TIELGLEVSP STLFAVASIL EGCAFLNGSP QNTLVPGALE LAWQHRVFVG GDDFKSGQTK VKSVLVDFLI GSGLKTMSIV SYNHLGNNDG ENLSAPLQFR SKEVSKSNVV DDMVQSNPVL YTPGEEPDHC VVIKYVPYVG DSKRALDEYT SELMLGGTNT LVLHNTCEDS LLAAPIMLDL ALLTELCQRV SFCTDMDPEP QTFHPVLSLL SFLFKAPLVP PGSPVVNALF RQRSCIENIL RACVGLPPQN HMLLEHKMER PGPSLKRVGP VAATYPMLNK KGPVPAATNG CTGDANGHLQ EEPPMPTT
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