About Interleukin-1 receptor accessory protein
Interleukin-1 receptor accessory protein (IL1RAP) is a protein
from Homo sapiens identified by UniProt accession
Q9NPH3, 570 residues long.
MolForge cross-references it against 0 known binders and
157 disease associations.
Target properties
| Protein name | Interleukin-1 receptor accessory protein |
|---|
| UniProt accession | Q9NPH3 |
|---|
| Gene | IL1RAP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 570 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (157)
Diseases linked to this target (Open Targets).
- interleukin 1 Receptor accessory protein measurement · score 0.48
- blood protein measurement · score 0.46
- psoriasis · score 0.39
- protein measurement · score 0.38
- psoriasis 14, pustular · score 0.38
- immune system disease · score 0.37
- chronic obstructive pulmonary disease · score 0.34
- visual perception measurement · score 0.31
- amyloid plaque accumulation rate · score 0.31
- eosinophil count · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NPH3-F1 | alphafold | PREDICTED | 86.07 | — |
Amino-acid sequence (570 residues)
MTLLWCVVSL YFYGILQSDA SERCDDWGLD TMRQIQVFED EPARIKCPLF EHFLKFNYST AHSAGLTLIW YWTRQDRDLE EPINFRLPEN RISKEKDVLW FRPTLLNDTG NYTCMLRNTT YCSKVAFPLE VVQKDSCFNS PMKLPVHKLY IEYGIQRITC PNVDGYFPSS VKPTITWYMG CYKIQNFNNV IPEGMNLSFL IALISNNGNY TCVVTYPENG RTFHLTRTLT VKVVGSPKNA VPPVIHSPND HVVYEKEPGE ELLIPCTVYF SFLMDSRNEV WWTIDGKKPD DITIDVTINE SISHSRTEDE TRTQILSIKK VTSEDLKRSY VCHARSAKGE VAKAAKVKQK VPAPRYTVEL ACGFGATVLL VVILIVVYHV YWLEMVLFYR AHFGTDETIL DGKEYDIYVS YARNAEEEEF VLLTLRGVLE NEFGYKLCIF DRDSLPGGIV TDETLSFIQK SRRLLVVLSP NYVLQGTQAL LELKAGLENM ASRGNINVIL VQYKAVKETK VKELKRAKTV LTVIKWKGEK SKYPQGRFWK QLQVAMPVKK SPRRSSSDEQ GLSYSSLKNV
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