Transmembrane protein 138 (TMEM138)

About Transmembrane protein 138

Transmembrane protein 138 (TMEM138) is a protein from Homo sapiens identified by UniProt accession Q9NPI0, 162 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.

Target properties

Protein name	Transmembrane protein 138
UniProt accession	Q9NPI0
Gene	TMEM138
Organism	Homo sapiens
Length	162 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (22)

Diseases linked to this target (Open Targets).

Joubert syndrome with oculorenal defect · score 0.78
Joubert syndrome and related disorders · score 0.34
Meckel syndrome · score 0.26
ciliopathy · score 0.19
Joubert syndrome · score 0.19
genetic disorder · score 0.15
refractive error measurement · score 0.03
body height · score 0.03
skin pigmentation · score 0.02
systemic juvenile idiopathic arthritis · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NPI0-F1	alphafold	PREDICTED	86.58	—

Amino-acid sequence (162 residues)

MLQTSNYSLV LSLQFLLLSY DLFVNSFSEL LQKTPVIQLV LFIIQDIAVL FNIIIIFLMF FNTFVFQAGL VNLLFHKFKG TIILTAVYFA LSISLHVWVM NLRWKNSNSF IWTDGLQMLF VFQRLAAVLY CYFYKRTAVR LGDPHFYQDS LWLRKEFMQV RR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards