About Bromodomain-containing protein 7
Bromodomain-containing protein 7 (BRD7) is a protein
from Homo sapiens identified by UniProt accession
Q9NPI1, 651 residues long.
MolForge cross-references it against 0 known binders and
202 disease associations.
Target properties
| Protein name | Bromodomain-containing protein 7 |
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| UniProt accession | Q9NPI1 |
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| Gene | BRD7 |
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| Organism | Homo sapiens |
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| Length | 651 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (202)
Diseases linked to this target (Open Targets).
- hepatocellular carcinoma · score 0.51
- neurodegenerative disease · score 0.34
- melanoma · score 0.32
- Granular Cell Tumor · score 0.26
- granular cell cancer · score 0.26
- breast adenocarcinoma · score 0.25
- Thyroid preparation use measurement · score 0.21
- inflammatory bowel disease · score 0.21
- squamous cell lung carcinoma · score 0.18
- gastric adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NPI1-F1 | alphafold | PREDICTED | 64.65 | — |
Amino-acid sequence (651 residues)
MGKKHKKHKS DKHLYEEYVE KPLKLVLKVG GNEVTELSTG SSGHDSSLFE DKNDHDKHKD RKRKKRKKGE KQIPGEEKGR KRRRVKEDKK KRDRDRVENE AEKDLQCHAP VRLDLPPEKP LTSSLAKQEE VEQTPLQEAL NQLMRQLQRK DPSAFFSFPV TDFIAPGYSM IIKHPMDFST MKEKIKNNDY QSIEELKDNF KLMCTNAMIY NKPETIYYKA AKKLLHSGMK ILSQERIQSL KQSIDFMADL QKTRKQKDGT DTSQSGEDGG CWQREREDSG DAEAHAFKSP SKENKKKDKD MLEDKFKSNN LEREQEQLDR IVKESGGKLT RRLVNSQCEF ERRKPDGTTT LGLLHPVDPI VGEPGYCPVR LGMTTGRLQS GVNTLQGFKE DKRNKVTPVL YLNYGPYSSY APHYDSTFAN ISKDDSDLIY STYGEDSDLP SDFSIHEFLA TCQDYPYVMA DSLLDVLTKG GHSRTLQEME MSLPEDEGHT RTLDTAKEME ITEVEPPGRL DSSTQDRLIA LKAVTNFGVP VEVFDSEEAE IFQKKLDETT RLLRELQEAQ NERLSTRPPP NMICLLGPSY REMHLAEQVT NNLKELAQQV TPGDIVSTYG VRKAMGISIP SPVMENNFVD LTEDTEEPKK TDVAECGPGG S
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