Nicotinamide riboside kinase 2 (NMRK2)

About Nicotinamide riboside kinase 2

Nicotinamide riboside kinase 2 (NMRK2) is a protein from Homo sapiens identified by UniProt accession Q9NPI5, 230 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.

Target properties

Protein name	Nicotinamide riboside kinase 2
UniProt accession	Q9NPI5
Gene	NMRK2
Organism	Homo sapiens
Length	230 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (55)

Diseases linked to this target (Open Targets).

age at menopause · score 0.26
creatinine measurement · score 0.16
glomerular filtration rate · score 0.13
pseudohypoparathyroidism type 2 · score 0.05
hypoparathyroidism, familial isolated, 2 · score 0.05
isolated hyperchlorhidrosis · score 0.04
Familial isolated hypoparathyroidism · score 0.04
hearing loss-familial salivary gland insensitivity to aldosterone syndrome · score 0.04
Dilated cardiomyopathy · score 0.04
familial isolated hypoparathyroidism due to agenesis of parathyroid gland · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NPI5-F1	alphafold	PREDICTED	87.72	—

Amino-acid sequence (230 residues)

MKLIVGIGGM TNGGKTTLTN SLLRALPNCC VIHQDDFFKP QDQIAVGEDG FKQWDVLESL DMEAMLDTVQ AWLSSPQKFA RAHGVSVQPE ASDTHILLLE GFLLYSYKPL VDLYSRRYFL TVPYEECKWR RSTRNYTVPD PPGLFDGHVW PMYQKYRQEM EANGVEVVYL DGMKSREELF REVLEDIQNS LLNRSQESAP SPARPARTQG PGRGCGHRTA RPAASQQDSM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards