About mRNA-decapping enzyme 1A
mRNA-decapping enzyme 1A (DCP1A) is a protein
from Homo sapiens identified by UniProt accession
Q9NPI6, 582 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | mRNA-decapping enzyme 1A |
|---|
| UniProt accession | Q9NPI6 |
|---|
| Gene | DCP1A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 582 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (61)
Diseases linked to this target (Open Targets).
- hypertension · score 0.12
- systolic blood pressure · score 0.09
- Agents acting on the renin-angiotensin system use measurement · score 0.08
- diastolic blood pressure · score 0.08
- Calcium channel blocker use measurement · score 0.08
- mean arterial pressure · score 0.07
- cardiovascular disease · score 0.07
- heart rate · score 0.07
- schizophrenia · score 0.06
- self reported educational attainment · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NPI6-F1 | alphafold | PREDICTED | 57.78 | — |
Amino-acid sequence (582 residues)
MEALSRAGQE MSLAALKQHD PYITSIADLT GQVALYTFCP KANQWEKTDI EGTLFVYRRS ASPYHGFTIV NRLNMHNLVE PVNKDLEFQL HEPFLLYRNA SLSIYSIWFY DKNDCHRIAK LMADVVEEET RRSQQAARDK QSPSQANGCS DHRPIDILEM LSRAKDEYER NQMGDSNISS PGLQPSTQLS NLGSTETLEE MPSGSQDKSA PSGHKHLTVE ELFGTSLPKE QPAVVGLDSE EMERLPGDAS QKEPNSFLPF PFEQLGGAPQ SETLGVPSAA HHSVQPEITT PVLITPASIT QSNEKHAPTY TIPLSPVLSP TLPAEAPTAQ VPPSLPRNST MMQAVKTTPR QRSPLLNQPV PELSHASLIA NQSPFRAPLN VTNTAGTSLP SVDLLQKLRL TPQHDQIQTQ PLGKGAMVAS FSPAAGQLAT PESFIEPPSK TAAARVAASA SLSNMVLAPL QSMQQNQDPE VFVQPKVLSS AIPVAGAPLV TATTTAVSSV LLAPSVFQQT VTRSSDLERK ASSPSPLTIG TPESQRKPSI ILSKSQLQDT LIHLIKNDSS FLSTLHEVYL QVLTKNKDNH NL
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