About Lysine-rich coiled-coil protein 1
Lysine-rich coiled-coil protein 1 (KRCC1) is a protein
from Homo sapiens identified by UniProt accession
Q9NPI7, 259 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | Lysine-rich coiled-coil protein 1 |
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| UniProt accession | Q9NPI7 |
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| Gene | KRCC1 |
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| Organism | Homo sapiens |
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| Length | 259 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (19)
Diseases linked to this target (Open Targets).
- IGF-1 measurement · score 0.29
- mitochondrial heteroplasmy measurement · score 0.02
- juvenile dermatomyositis · score 0.01
- pachyonychia congenita · score 0.01
- hepatocellular carcinoma · score 0.01
- ulcerative colitis · score 0.01
- metastatic melanoma · score 0.01
- chronic kidney disease · score 0.00
- invasive breast ductal carcinoma · score 0.00
- Down syndrome · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NPI7-F1 | alphafold | PREDICTED | 58.38 | — |
Amino-acid sequence (259 residues)
MKHSKKTYDS FQDELEDYIK VQKARGLEPK TCFRKMKGDY LETCGYKGEV NSRPTYRMFD QRLPSETIQT YPRSCNIPQT VENRLPQWLP AHDSRLRLDS LSYCQFTRDC FSEKPVPLNF NQQEYICGSH GVEHRVYKHF SSDNSTSTHQ ASHKQIHQKR KRHPEEGREK SEEERSKHKR KKSCEEIDLD KHKSIQRKKT EVEIETVHVS TEKLKNRKEK KSRDVVSKKE ERKRTKKKKE QGQERTEEEM LWDQSILGF
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