Fanconi anemia group F protein (FANCF)

About Fanconi anemia group F protein

Fanconi anemia group F protein (FANCF) is a protein from Homo sapiens identified by UniProt accession Q9NPI8, 374 residues long. MolForge cross-references it against 0 known binders and 280 disease associations.

Target properties

Protein name	Fanconi anemia group F protein
UniProt accession	Q9NPI8
Gene	FANCF
Organism	Homo sapiens
Length	374 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (280)

Diseases linked to this target (Open Targets).

Fanconi anemia complementation group F · score 0.81
Fanconi anemia · score 0.75
acute myeloid leukemia · score 0.46
myelodysplastic syndrome · score 0.46
leukemia · score 0.46
prostate carcinoma · score 0.37
head and neck malignant neoplasia · score 0.37
Abnormal radial ray morphology · score 0.37
superficial spreading melanoma · score 0.37
hepatocellular carcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NPI8-F1	alphafold	PREDICTED	78.60	—

Amino-acid sequence (374 residues)

MESLLQHLDR FSELLAVSST TYVSTWDPAT VRRALQWARY LRHIHRRFGR HGPIRTALER RLHNQWRQEG GFGRGPVPGL ANFQALGHCD VLLSLRLLEN RALGDAARYH LVQQLFPGPG VRDADEETLQ ESLARLARRR SAVHMLRFNG YRENPNLQED SLMKTQAELL LERLQEVGKA EAERPARFLS SLWERLPQNN FLKVIAVALL QPPLSRRPQE ELEPGIHKSP GEGSQVLVHW LLGNSEVFAA FCRALPAGLL TLVTSRHPAL SPVYLGLLTD WGQRLHYDLQ KGIWVGTESQ DVPWEELHNR FQSLCQAPPP LKDKVLTALE TCKAQDGDFE VPGLSIWTDL LLALRSGAFR KRQVLGLSAG LSSV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards