Inward rectifier potassium channel 16 (KCNJ16)

About Inward rectifier potassium channel 16

Inward rectifier potassium channel 16 (KCNJ16) is a protein from Homo sapiens identified by UniProt accession Q9NPI9, 418 residues long. MolForge cross-references it against 0 known binders and 171 disease associations.

Target properties

Protein name	Inward rectifier potassium channel 16
UniProt accession	Q9NPI9
Gene	KCNJ16
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (171)

Diseases linked to this target (Open Targets).

hypokalemic tubulopathy and deafness · score 0.68
body height · score 0.47
appendicular lean mass · score 0.41
cortical surface area measurement · score 0.38
snoring measurement · score 0.35
BMI-adjusted waist circumference · score 0.35
birth weight · score 0.34
sitting height measurement · score 0.34
hereditary breast ovarian cancer syndrome · score 0.34
PMM2-congenital disorder of glycosylation · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NPI9-F1	alphafold	PREDICTED	78.13	—

Amino-acid sequence (418 residues)

MSYYGSSYHI INADAKYPGY PPEHIIAEKR RARRRLLHKD GSCNVYFKHI FGEWGSYVVD IFTTLVDTKW RHMFVIFSLS YILSWLIFGS VFWLIAFHHG DLLNDPDITP CVDNVHSFTG AFLFSLETQT TIGYGYRCVT EECSVAVLMV ILQSILSCII NTFIIGAALA KMATARKRAQ TIRFSYFALI GMRDGKLCLM WRIGDFRPNH VVEGTVRAQL LRYTEDSEGR MTMAFKDLKL VNDQIILVTP VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV PREILWGHRF NDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ LHIEKAPPVR ESCTSDTKAR RRSFSAVAIV SSCENPEETT TSATHEYRET PYQKALLTLN RISVESQM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards