Proline-rich nuclear receptor coactivator 2 (PNRC2)

About Proline-rich nuclear receptor coactivator 2

Proline-rich nuclear receptor coactivator 2 (PNRC2) is a protein from Homo sapiens identified by UniProt accession Q9NPJ4, 139 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Proline-rich nuclear receptor coactivator 2
UniProt accession	Q9NPJ4
Gene	PNRC2
Organism	Homo sapiens
Length	139 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

Red cell distribution width · score 0.24
chronotype measurement · score 0.14
lymphocyte count · score 0.07
appendicular lean mass · score 0.06
infect · score 0.02
infection · score 0.02
ovarian carcinoma · score 0.01
viral disease · score 0.01
renal cell carcinoma · score 0.01
Obesity · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NPJ4-F1	alphafold	PREDICTED	67.64	—

Amino-acid sequence (139 residues)

MGGGERYNIP APQSRNVSKN QQQLNRQKTK EQNSQMKIVH KKKERGHGYN SSAAAWQAMQ NGGKNKNFPN NQSWNSSLSG PRLLFKSQAN QNYAGAKFSE PPSPSVLPKP PSHWVPVSFN PSDKEIMTFQ LKTLLKVQV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards