About Mediator of RNA polymerase II transcription subunit 4
Mediator of RNA polymerase II transcription subunit 4 (MED4) is a protein
from Homo sapiens identified by UniProt accession
Q9NPJ6, 270 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Mediator of RNA polymerase II transcription subunit 4 |
|---|
| UniProt accession | Q9NPJ6 |
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| Gene | MED4 |
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| Organism | Homo sapiens |
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| Length | 270 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- creatinine measurement · score 0.28
- leukopenia · score 0.27
- urate measurement · score 0.27
- glomerular filtration rate · score 0.26
- cystatin C measurement · score 0.25
- alopecia · score 0.23
- red blood cell density measurement · score 0.22
- uric acid measurement · score 0.17
- serum urea measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NPJ6-F1 | alphafold | PREDICTED | 73.37 | — |
Amino-acid sequence (270 residues)
MAASSSGEKE KERLGGGLGV AGGNSTRERL LSALEDLEVL SRELIEMLAI SRNQKLLQAG EENQVLELLI HRDGEFQELM KLALNQGKIH HEMQVLEKEV EKRDSDIQQL QKQLKEAEQI LATAVYQAKE KLKSIEKARK GAISSEEIIK YAHRISASNA VCAPLTWVPG DPRRPYPTDL EMRSGLLGQM NNPSTNGVNG HLPGDALAAG RLPDVLAPQY PWQSNDMSMN MLPPNHSSDF LLEPPGHNKE NEDDVEIMST DSSSSSSESD
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