About Chaperone Ric-8A
Chaperone Ric-8A (RIC8A) is a protein
from Homo sapiens identified by UniProt accession
Q9NPQ8, 531 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | Chaperone Ric-8A |
|---|
| UniProt accession | Q9NPQ8 |
|---|
| Gene | RIC8A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 531 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (61)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.29
- viral meningitis · score 0.21
- uterine fibroid · score 0.17
- cataract · score 0.15
- mean corpuscular volume · score 0.14
- mean corpuscular hemoglobin concentration · score 0.13
- erythrocyte count · score 0.13
- brain aneurysm · score 0.13
- platelet count · score 0.12
- red blood cell density measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NPQ8-F1 | alphafold | PREDICTED | 90.05 | — |
Amino-acid sequence (531 residues)
MEPRAVAEAV ETGEEDVIME ALRSYNQEHS QSFTFDDAQQ EDRKRLAELL VSVLEQGLPP SHRVIWLQSV RILSRDRNCL DPFTSRQSLQ ALACYADISV SEGSVPESAD MDVVLESLKC LCNLVLSSPV AQMLAAEARL VVKLTERVGL YRERSFPHDV QFFDLRLLFL LTALRTDVRQ QLFQELKGVR LLTDTLELTL GVTPEGNPPP TLLPSQETER AMEILKVLFN ITLDSIKGEV DEEDAALYRH LGTLLRHCVM IATAGDRTEE FHGHAVNLLG NLPLKCLDVL LTLEPHGDST EFMGVNMDVI RALLIFLEKR LHKTHRLKES VAPVLSVLTE CARMHRPARK FLKAQVLPPL RDVRTRPEVG EMLRNKLVRL MTHLDTDVKR VAAEFLFVLC SESVPRFIKY TGYGNAAGLL AARGLMAGGR PEGQYSEDED TDTDEYKEAK ASINPVTGRV EEKPPNPMEG MTEEQKEHEA MKLVTMFDKL SRNRVIQPMG MSPRGHLTSL QDAMCETMEQ QLSSDPDSDP D
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