About Protein GPR108
Protein GPR108 (GPR108) is a protein
from Homo sapiens identified by UniProt accession
Q9NPR9, 543 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Protein GPR108 |
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| UniProt accession | Q9NPR9 |
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| Gene | GPR108 |
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| Organism | Homo sapiens |
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| Length | 543 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (41)
Diseases linked to this target (Open Targets).
- aspartate aminotransferase measurement · score 0.07
- serum gamma-glutamyl transferase measurement · score 0.05
- Gollop-Wolfgang complex · score 0.05
- tibia, hypoplasia or aplasia of, with polydactyly · score 0.04
- Blount disease · score 0.04
- acheiropody · score 0.04
- acromesomelic dysplasia 2C, Hunter-Thompson type · score 0.04
- Acromesomelic dysplasia, Hunter-Thomson type · score 0.04
- metaphyseal dysostosis-intellectual disability-conductive deafness syndrome · score 0.04
- syndactyly type 4 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NPR9-F1 | alphafold | PREDICTED | 75.31 | — |
Amino-acid sequence (543 residues)
MAVSERRGLG RGSPAEWGQR LLLVLLLGGC SGRIHQLALT GEKRADIQLN SFGFYTNGSL EVELSVLRLG LREAEEKSLL VGFSLSRVRS GRVRSYSTRD FQDCPLQKNS SSFLVLFLIN TKDLQVQVRK YGEQKTLFIF PGLLPEAPSK PGLPKPQATV PRKVDGGGTS AASKPKSTPA VIQGPSGKDK DLVLGLSHLN NSYNFSFHVV IGSQAEEGQY SLNFHNCNNS VPGKEHPFDI TVMIREKNPD GFLSAAEMPL FKLYMVMSAC FLAAGIFWVS ILCRNTYSVF KIHWLMAALA FTKSISLLFH SINYYFINSQ GHPIEGLAVM YYIAHLLKGA LLFITIALIG SGWAFIKYVL SDKEKKVFGI VIPMQVLANV AYIIIESREE GASDYVLWKE ILFLVDLICC GAILFPVVWS IRHLQDASGT DGKVAVNLAK LKLFRHYYVM VICYVYFTRI IAILLQVAVP FQWQWLYQLL VEGSTLAFFV LTGYKFQPTG NNPYLQLPQE DEEDVQMEQV MTDSGFREGL SKVNKTASGR ELL
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