About G-protein coupled receptor family C group 5 member C
G-protein coupled receptor family C group 5 member C (GPRC5C) is a protein
from Homo sapiens identified by UniProt accession
Q9NQ84, 441 residues long.
MolForge cross-references it against 0 known binders and
97 disease associations.
Target properties
| Protein name | G-protein coupled receptor family C group 5 member C |
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| UniProt accession | Q9NQ84 |
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| Gene | GPRC5C |
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| Organism | Homo sapiens |
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| Length | 441 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (97)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.38
- low density lipoprotein cholesterol measurement · score 0.26
- sleep duration · score 0.26
- blood protein measurement · score 0.19
- Blackfan-Diamond anemia · score 0.06
- hemoglobin E-beta-thalassemia syndrome · score 0.06
- dehydrated hereditary stomatocytosis · score 0.05
- Adult-onset autosomal recessive sideroblastic anemia · score 0.05
- hemoglobin D disease · score 0.05
- Rh deficiency syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NQ84-F1 | alphafold | PREDICTED | 70.82 | — |
Amino-acid sequence (441 residues)
MAIHKALVMC LGLPLFLFPG AWAQGHVPPG CSQGLNPLYY NLCDRSGAWG IVLEAVAGAG IVTTFVLTII LVASLPFVQD TKKRSLLGTQ VFFLLGTLGL FCLVFACVVK PDFSTCASRR FLFGVLFAIC FSCLAAHVFA LNFLARKNHG PRGWVIFTVA LLLTLVEVII NTEWLIITLV RGSGEGGPQG NSSAGWAVAS PCAIANMDFV MALIYVMLLL LGAFLGAWPA LCGRYKRWRK HGVFVLLTTA TSVAIWVVWI VMYTYGNKQH NSPTWDDPTL AIALAANAWA FVLFYVIPEV SQVTKSSPEQ SYQGDMYPTR GVGYETILKE QKGQSMFVEN KAFSMDEPVA AKRPVSPYSG YNGQLLTSVY QPTEMALMHK VPSEGAYDII LPRATANSQV MGSANSTLRA EDMYSAQSHQ AATPPKDGKN SQVFRNPYVW D
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