About Ferry endosomal RAB5 effector complex subunit 3
Ferry endosomal RAB5 effector complex subunit 3 (FERRY3) is a protein
from Homo sapiens identified by UniProt accession
Q9NQ89, 552 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Ferry endosomal RAB5 effector complex subunit 3 |
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| UniProt accession | Q9NQ89 |
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| Gene | FERRY3 |
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| Organism | Homo sapiens |
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| Length | 552 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (35)
Diseases linked to this target (Open Targets).
- autosomal recessive non-syndromic intellectual disability · score 0.61
- alkaline phosphatase measurement · score 0.34
- blood phosphate measurement · score 0.31
- calcium measurement · score 0.27
- Intellectual disability · score 0.26
- attention deficit hyperactivity disorder · score 0.26
- Hypotonia · score 0.26
- glomerular filtration rate · score 0.22
- phosphorus measurement · score 0.18
- genetic disorder · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NQ89-F1 | alphafold | PREDICTED | 83.91 | — |
Amino-acid sequence (552 residues)
MKKNRERFCN REREFVYKFK VGSQCLELRV PLKFPVQENA SHLHGRLMLL HSLPCFIEKD LKEALTQFIE EESLSDYDRD AEASLAAVKS GEVDLHQLAS TWAKAYAETT LEHARPEEPS WDEDFADVYH DLIHSPASET LLNLEHNYFV SISELIGERD VELKKLRERQ GIEMEKVMQE LGKSLTDQDV NSLAAQHFES QQDLENKWSN ELKQSTAIQK QEYQEWVIKL HQDLKNPNNS SLSEEIKVQP SQFRESVEAI GRIYEEQRKL EESFTIHLGA QLKTMHNLRL LRADMLDFCK HKRNHRSGVK LHRLQTALSL YSTSLCGLVL LVDNRINSYS GIKRDFATVC QECTDFHFPR IEEQLEVVQQ VVLYARTQRR SKLKESLDSG NQNGGNDDKT KNAERNYLNV LPGEFYITRH SNLSEIHVAF HLCVDDHVKS GNITARDPAI MGLRNILKVC CTHDITTISI PLLLVHDMSE EMTIPWCLRR AELVFKCVKG FMMEMASWDG GISRTVQFLV PQSISEEMFY QLSNMLPQIF RVSSTLTLTS KH
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