About Transcription factor 7-like 2
Transcription factor 7-like 2 (TCF7L2) is a protein
from Homo sapiens identified by UniProt accession
Q9NQB0, 619 residues long.
MolForge cross-references it against 0 known binders and
558 disease associations.
Target properties
| Protein name | Transcription factor 7-like 2 |
|---|
| UniProt accession | Q9NQB0 |
|---|
| Gene | TCF7L2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 619 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (558)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.66
- colorectal adenocarcinoma · score 0.64
- diabetes mellitus · score 0.54
- body mass index · score 0.53
- Myopia · score 0.53
- glucose measurement · score 0.51
- breast carcinoma · score 0.51
- fasting blood glucose measurement · score 0.51
- neurodegenerative disease · score 0.50
- sex hormone-binding globulin measurement · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NQB0-F1 | alphafold | PREDICTED | 52.99 | — |
Amino-acid sequence (619 residues)
MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN ESETNQNSSS DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY PGYPFIMIPD LTSPYLPNGS LSPTARTLHF QSGSTHYSAY KTIEHQIAVQ YLQMKWPLLD VQAGSLQSRQ ALKDARSPSP AHIVSNKVPV VQHPHHVHPL TPLITYSNEH FTPGNPPPHL PADVDPKTGI PRPPHPPDIS PYYPLSPGTV GQIPHPLGWL VPQQGQPVYP ITTGGFRHPY PTALTVNASM SRFPPHMVPP HHTLHTTGIP HPAIVTPTVK QESSQSDVGS LHSSKHQDSK KEEEKKKPHI KKPLNAFMLY MKEMRAKVVA ECTLKESAAI NQILGRRWHA LSREEQAKYY ELARKERQLH MQLYPGWSAR DNYGKKKKRK RDKQPGETNE HSECFLNPCL SLPPITDLSA PKKCRARFGL DQQNNWCGPC RRKKKCVRYI QGEGSCLSPP SSDGSLLDSP PPSPNLLGSP PRDAKSQTEQ TQPLSLSLKP DPLAHLSMMP PPPALLLAEA THKASALCPN GALDLPPAAL QPAAPSSSIA QPSTSSLHSH SSLAGTQPQP LSLVTKSLE
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