About DNA polymerase epsilon subunit 4
DNA polymerase epsilon subunit 4 (POLE4) is a protein
from Homo sapiens identified by UniProt accession
Q9NR33, 117 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | DNA polymerase epsilon subunit 4 |
|---|
| UniProt accession | Q9NR33 |
|---|
| Gene | POLE4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 117 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (38)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- endometrial cancer · score 0.23
- venous thromboembolism · score 0.09
- Hoyeraal-Hreidarsson syndrome · score 0.03
- Immunodeficiency with natural-killer cell deficiency and adrenal insufficiency · score 0.03
- primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency · score 0.03
- Fanconi anemia complementation group C · score 0.03
- Ataxia-telangiectasia · score 0.03
- Camurati-Engelmann disease · score 0.03
- MIRAGE syndrome · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NR33-F1 | alphafold | PREDICTED | 80.89 | — |
Amino-acid sequence (117 residues)
MAAAAAAGSG TPREEEGPAG EAAASQPQAP TSVPGARLSR LPLARVKALV KADPDVTLAG QEAIFILARA AELFVETIAK DAYCCAQQGK RKTLQRRDLD NAIEAVDEFA FLEGTLD
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