N-acetylneuraminate-9-phosphate synthase (NANS)

About N-acetylneuraminate-9-phosphate synthase

N-acetylneuraminate-9-phosphate synthase (NANS) is a protein from Homo sapiens identified by UniProt accession Q9NR45, 359 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	N-acetylneuraminate-9-phosphate synthase
UniProt accession	Q9NR45
Gene	NANS
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

spondyloepimetaphyseal dysplasia, Genevieve type · score 0.77
neurodegenerative disease · score 0.50
pancreatic adenocarcinoma · score 0.21
genetic disorder · score 0.19
reticulocyte count · score 0.14
eosinophil count · score 0.08
primary biliary cirrhosis · score 0.08
high density lipoprotein cholesterol measurement · score 0.08
eosinophil percentage of leukocytes · score 0.08
apolipoprotein A 1 measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NR45-F1	alphafold	PREDICTED	96.00	—

Amino-acid sequence (359 residues)

MPLELELCPG RWVGGQHPCF IIAEIGQNHQ GDLDVAKRMI RMAKECGADC AKFQKSELEF KFNRKALERP YTSKHSWGKT YGEHKRHLEF SHDQYRELQR YAEEVGIFFT ASGMDEMAVE FLHELNVPFF KVGSGDTNNF PYLEKTAKKG RPMVISSGMQ SMDTMKQVYQ IVKPLNPNFC FLQCTSAYPL QPEDVNLRVI SEYQKLFPDI PIGYSGHETG IAISVAAVAL GAKVLERHIT LDKTWKGSDH SASLEPGELA ELVRSVRLVE RALGSPTKQL LPCEMACNEK LGKSVVAKVK IPEGTILTMD MLTVKVGEPK GYPPEDIFNL VGKKVLVTVE EDDTIMEELV DNHGKKIKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards