About Cytochrome P450 26B1
Cytochrome P450 26B1 (CYP26B1) is a protein
from Homo sapiens identified by UniProt accession
Q9NR63, 512 residues long.
MolForge cross-references it against 0 known binders and
267 disease associations.
Target properties
| Protein name | Cytochrome P450 26B1 |
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| UniProt accession | Q9NR63 |
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| Gene | CYP26B1 |
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| Organism | Homo sapiens |
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| Length | 512 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (267)
Diseases linked to this target (Open Targets).
- lethal occipital encephalocele-skeletal dysplasia syndrome · score 0.70
- heel bone mineral density · score 0.44
- body height · score 0.42
- craniosynostosis · score 0.41
- vital capacity · score 0.38
- schizophrenia · score 0.30
- serum metabolite measurement · score 0.30
- mitochondrial heteroplasmy measurement · score 0.26
- appendicular lean mass · score 0.23
- mean corpuscular hemoglobin concentration · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NR63-F1 | alphafold | PREDICTED | 90.65 | — |
Amino-acid sequence (512 residues)
MLFEGLDLVS ALATLAACLV SVTLLLAVSQ QLWQLRWAAT RDKSCKLPIP KGSMGFPLIG ETGHWLLQGS GFQSSRREKY GNVFKTHLLG RPLIRVTGAE NVRKILMGEH HLVSTEWPRS TRMLLGPNTV SNSIGDIHRN KRKVFSKIFS HEALESYLPK IQLVIQDTLR AWSSHPEAIN VYQEAQKLTF RMAIRVLLGF SIPEEDLGHL FEVYQQFVDN VFSLPVDLPF SGYRRGIQAR QILQKGLEKA IREKLQCTQG KDYLDALDLL IESSKEHGKE MTMQELKDGT LELIFAAYAT TASASTSLIM QLLKHPTVLE KLRDELRAHG ILHSGGCPCE GTLRLDTLSG LRYLDCVIKE VMRLFTPISG GYRTVLQTFE LDGFQIPKGW SVMYSIRDTH DTAPVFKDVN VFDPDRFSQA RSEDKDGRFH YLPFGGGVRT CLGKHLAKLF LKVLAVELAS TSRFELATRT FPRITLVPVL HPVDGLSVKF FGLDSNQNEI LPETEAMLSA TV
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