Peroxisomal membrane protein 2 (PXMP2)

About Peroxisomal membrane protein 2

Peroxisomal membrane protein 2 (PXMP2) is a protein from Homo sapiens identified by UniProt accession Q9NR77, 195 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Protein name	Peroxisomal membrane protein 2
UniProt accession	Q9NR77
Gene	PXMP2
Organism	Homo sapiens
Length	195 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (35)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin · score 0.25
mean corpuscular hemoglobin concentration · score 0.19
reticulocyte measurement · score 0.19
Red cell distribution width · score 0.18
health study participation · score 0.13
colorectal cancer, susceptibility to, 12 · score 0.12
facial dysmorphism-immunodeficiency-livedo-short stature syndrome · score 0.12
intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency · score 0.12
Facial dysmorphism - immunodeficiency - livedo - short stature · score 0.12
mean corpuscular volume · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NR77-F1	alphafold	PREDICTED	85.15	—

Amino-acid sequence (195 residues)

MAPAASRLRA EAGLGALPRR ALAQYLLFLR LYPVLTKAAT SGILSALGNF LAQMIEKKRK KENSRSLDVG GPLRYAVYGF FFTGPLSHFF YFFMEHWIPP EVPLAGLRRL LLDRLVFAPA FLMLFFLIMN FLEGKDASAF AAKMRGGFWP ALRMNWRVWT PLQFININYV PLKFRVLFAN LAALFWYAYL ASLGK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards