Sialin (SLC17A5)

About Sialin

Sialin (SLC17A5) is a protein from Homo sapiens identified by UniProt accession Q9NRA2, 495 residues long. MolForge cross-references it against 0 known binders and 119 disease associations.

Target properties

Protein name	Sialin
UniProt accession	Q9NRA2
Gene	SLC17A5
Organism	Homo sapiens
Length	495 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (119)

Diseases linked to this target (Open Targets).

free sialic acid storage disease, infantile form · score 0.82
Salla disease · score 0.81
neurodegenerative disease · score 0.50
intermediate severe Salla disease · score 0.45
genetic disorder · score 0.41
lysosomal storage disease · score 0.37
hydrops fetalis · score 0.37
Hydrops fetalis · score 0.37
inborn errors of metabolism · score 0.37
free sialic acid storage disease · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NRA2-F1	alphafold	PREDICTED	84.15	—

Amino-acid sequence (495 residues)

MRSPVRDLAR NDGEESTDRT PLLPGAPRAE AAPVCCSARY NLAILAFFGF FIVYALRVNL SVALVDMVDS NTTLEDNRTS KACPEHSAPI KVHHNQTGKK YQWDAETQGW ILGSFFYGYI ITQIPGGYVA SKIGGKMLLG FGILGTAVLT LFTPIAADLG VGPLIVLRAL EGLGEGVTFP AMHAMWSSWA PPLERSKLLS ISYAGAQLGT VISLPLSGII CYYMNWTYVF YFFGTIGIFW FLLWIWLVSD TPQKHKRISH YEKEYILSSL RNQLSSQKSV PWVPILKSLP LWAIVVAHFS YNWTFYTLLT LLPTYMKEIL RFNVQENGFL SSLPYLGSWL CMILSGQAAD NLRAKWNFST LCVRRIFSLI GMIGPAVFLV AAGFIGCDYS LAVAFLTIST TLGGFCSSGF SINHLDIAPS YAGILLGITN TFATIPGMVG PVIAKSLTPD NTVGEWQTVF YIAAAINVFG AIFFTLFAKG EVQNWALNDH HGHRH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards