NAD-dependent protein deacetylase sirtuin-7 (SIRT7)

About NAD-dependent protein deacetylase sirtuin-7

NAD-dependent protein deacetylase sirtuin-7 (SIRT7) is a protein from Homo sapiens identified by UniProt accession Q9NRC8, 400 residues long. MolForge cross-references it against 0 known binders and 255 disease associations.

Target properties

Protein name	NAD-dependent protein deacetylase sirtuin-7
UniProt accession	Q9NRC8
Gene	SIRT7
Organism	Homo sapiens
Length	400 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (255)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.31
hepatocellular carcinoma · score 0.12
neoplasm · score 0.11
cancer · score 0.10
melanoma · score 0.10
non-small cell lung carcinoma · score 0.09
breast cancer · score 0.09
insulin resistance · score 0.08
oral squamous cell carcinoma · score 0.08
Pallister-Hall syndrome · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NRC8-F1	alphafold	PREDICTED	87.99	—

Amino-acid sequence (400 residues)

MAAGGLSRSE RKAAERVRRL REEQQRERLR QVSRILRKAA AERSAEEGRL LAESADLVTE LQGRSRRREG LKRRQEEVCD DPEELRGKVR ELASAVRNAK YLVVYTGAGI STAASIPDYR GPNGVWTLLQ KGRSVSAADL SEAEPTLTHM SITRLHEQKL VQHVVSQNCD GLHLRSGLPR TAISELHGNM YIEVCTSCVP NREYVRVFDV TERTALHRHQ TGRTCHKCGT QLRDTIVHFG ERGTLGQPLN WEAATEAASR ADTILCLGSS LKVLKKYPRL WCMTKPPSRR PKLYIVNLQW TPKDDWAALK LHGKCDDVMR LLMAELGLEI PAYSRWQDPI FSLATPLRAG EEGSHSRKSL CRSREEAPPG DRGAPLSSAP ILGGWFGRGC TKRTKRKKVT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards