About Teashirt homolog 2
Teashirt homolog 2 (TSHZ2) is a protein
from Homo sapiens identified by UniProt accession
Q9NRE2, 1034 residues long.
MolForge cross-references it against 0 known binders and
79 disease associations.
Target properties
| Protein name | Teashirt homolog 2 |
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| UniProt accession | Q9NRE2 |
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| Gene | TSHZ2 |
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| Organism | Homo sapiens |
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| Length | 1034 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (79)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.49
- waist-hip ratio · score 0.48
- BMI-adjusted waist circumference · score 0.46
- body fat percentage · score 0.45
- risk-taking behaviour · score 0.45
- urate measurement · score 0.43
- bone density · score 0.43
- glucose measurement · score 0.41
- type 2 diabetes mellitus · score 0.41
- BMI-adjusted hip circumference · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NRE2-F1 | alphafold | PREDICTED | 54.51 | — |
Amino-acid sequence (1034 residues)
MPRRKQQAPK RAAGYAQEEQ LKEEEEIKEE EEEEDSGSVA QLQGGNDTGT DEELETGPEQ KGCFSYQNSP GSHLSNQDAE NESLLSDASD QVSDIKSVCG RDASDKKAHT HVRLPNEAHN CMDKMTAVYA NILSDSYWSG LGLGFKLSNS ERRNCDTRNG SNKSDFDWHQ DALSKSLQQN LPSRSVSKPS LFSSVQLYRQ SSKMCGTVFT GASRFRCRQC SAAYDTLVEL TVHMNETGHY QDDNRKKDKL RPTSYSKPRK RAFQDMDKED AQKVLKCMFC GDSFDSLQDL SVHMIKTKHY QKVPLKEPVP TISSKMVTPA KKRVFDVNRP CSPDSTTGSF ADSFSSQKNA NLQLSSNNRY GYQNGASYTW QFEACKSQIL KCMECGSSHD TLQQLTTHMM VTGHFLKVTS SASKKGKQLV LDPLAVEKMQ SLSEAPNSDS LAPKPSSNSA SDCTASTTEL KKESKKERPE ETSKDEKVVK SEDYEDPLQK PLDPTIKYQY LREEDLEDGS KGGGDILKSL ENTVTTAINK AQNGAPSWSA YPSIHAAYQL SEGTKPPLPM GSQVLQIRPN LTNKLRPIAP KWKVMPLVSM PTHLAPYTQV KKESEDKDEA VKECGKESPH EEASSFSHSE GDSFRKSETP PEAKKTELGP LKEEEKLMKE GSEKEKPQPL EPTSALSNGC ALANHAPALP CINPLSALQS VLNNHLGKAT EPLRSPSCSS PSSSTISMFH KSNLNVMDKP VLSPASTRSA SVSRRYLFEN SDQPIDLTKS KSKKAESSQA QSCMSPPQKH ALSDIADMVK VLPKATTPKP ASSSRVPPMK LEMDVRRFED VSSEVSTLHK RKGRQSNWNP QHLLILQAQF ASSLFQTSEG KYLLSDLGPQ ERMQISKFTG LSMTTISHWL ANVKYQLRKT GGTKFLKNMD KGHPIFYCSD CASQFRTPST YISHLESHLG FQMKDMTRLS VDQQSKVEQE ISRVSSAQRS PETIAAEEDT DSKFKCKLCC RTFVSKHAVK LHLSKTHSKS PEHHSQFVTD VDEE
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