About SH2B adapter protein 1
SH2B adapter protein 1 (SH2B1) is a protein
from Homo sapiens identified by UniProt accession
Q9NRF2, 756 residues long.
MolForge cross-references it against 0 known binders and
285 disease associations.
Target properties
| Protein name | SH2B adapter protein 1 |
|---|
| UniProt accession | Q9NRF2 |
|---|
| Gene | SH2B1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 756 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (285)
Diseases linked to this target (Open Targets).
- severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency · score 0.48
- neurodegenerative disease · score 0.38
- distal 16p11.2 microdeletion syndrome · score 0.34
- primary ovarian insufficiency · score 0.28
- body mass index · score 0.26
- obesity · score 0.22
- body fat percentage · score 0.22
- waist circumference · score 0.22
- mathematical ability · score 0.21
- body weight · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NRF2-F1 | alphafold | PREDICTED | 57.28 | — |
Amino-acid sequence (756 residues)
MNGAPSPEDG ASPSSPPLPP PPPPSWREFC ESHARAAALD FARRFRLYLA SHPQYAGPGA EAAFSRRFAE LFLQHFEAEV ARASGSLSPP ILAPLSPGAE ISPHDLSLES CRVGGPLAVL GPSRSSEDLA GPLPSSVSSS STTSSKPKLK KRFSLRSVGR SVRGSVRGIL QWRGTVDPPS SAGPLETSSG PPVLGGNSNS NSSGGAGTVG RGLVSDGTSP GERWTHRFER LRLSRGGGAL KDGAGMVQRE ELLSFMGAEE AAPDPAGVGR GGGVAGPPSG GGGQPQWQKC RLLLRSEGEG GGGSRLEFFV PPKASRPRLS IPCSSITDVR TTTALEMPDR ENTFVVKVEG PSEYIMETVD AQHVKAWVSD IQECLSPGPC PATSPRPMTL PLAPGTSFLT RENTDSLELS CLNHSESLPS QDLLLGPSES NDRLSQGAYG GLSDRPSASI SPSSASIAAS HFDSMELLPP ELPPRIPIEE GPPTGTVHPL SAPYPPLDTP ETATGSFLFQ GEPEGGEGDQ PLSGYPWFHG MLSRLKAAQL VLTGGTGSHG VFLVRQSETR RGEYVLTFNF QGKAKHLRLS LNEEGQCRVQ HLWFQSIFDM LEHFRVHPIP LESGGSSDVV LVSYVPSSQR QQEPTTSHDP PQPPEPPSWT DPPQPGAEEA SRAPEVAAAA AAAAKERQEK EKAGGGGVPE ELVPVVELVP VVELEEAIAP GSEAQGAGSG GDAGVPPMVQ LQQSPLGGDG EEGGHPRAIN NQYSFV
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