About Striatin-4
Striatin-4 (STRN4) is a protein
from Homo sapiens identified by UniProt accession
Q9NRL3, 753 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Striatin-4 |
|---|
| UniProt accession | Q9NRL3 |
|---|
| Gene | STRN4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 753 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (50)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- limb-girdle muscular dystrophy · score 0.34
- autosomal recessive limb-girdle muscular dystrophy type 2I · score 0.34
- muscular dystrophy-dystroglycanopathy, type A · score 0.12
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A5 · score 0.12
- aspartate aminotransferase measurement · score 0.11
- C-reactive protein measurement · score 0.09
- type 1 diabetes mellitus · score 0.08
- cancer · score 0.07
- chronic lymphocytic leukemia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NRL3-F1 | alphafold | PREDICTED | 67.59 | — |
Amino-acid sequence (753 residues)
MMEERAAAAV AAAASSCRPL GSGAGPGPTG AAPVSAPAPG PGPAGKGGGG GGSPGPTAGP EPLSLPGILH FIQHEWARFE AEKARWEAER AELQAQVAFL QGERKGQENL KTDLVRRIKM LEYALKQERA KYHKLKFGTD LNQGEKKADV SEQVSNGPVE SVTLENSPLV WKEGRQLLRQ YLEEVGYTDT ILDMRSKRVR SLLGRSLELN GAVEPSEGAP RAPPGPAGLS GGESLLVKQI EEQIKRNAAG KDGKERLGGS VLGQIPFLQN CEDEDSDEDD ELDSVQHKKQ RVKLPSKALV PEMEDEDEED DSEDAINEFD FLGSGEDGEG APDPRRCTVD GSPHELESRR VKLQGILADL RDVDGLPPKV TGPPPGTPQP RPHEDVFIMD TIGGGEVSLG DLADLTVTND NDLSCDLSDS KDAFKKTWNP KFTLRSHYDG IRSLAFHHSQ SALLTASEDG TLKLWNLQKA VTAKKNAALD VEPIHAFRAH RGPVLAVAMG SNSEYCYSGG ADACIHSWKI PDLSMDPYDG YDPSVLSHVL EGHGDAVWGL AFSPTSQRLA SCSADGTVRI WDPSSSSPAC LCTFPTASEH GVPTSVAFTS TEPAHIVASF RSGDTVLYDM EVGSALLTLE SRGSSGPTQI NQVVSHPNQP LTITAHDDRG IRFLDNRTGK PVHSMVAHLD AVTCLAVDPN GAFLMSGSHD CSLRLWSLDN KTCVQEITAH RKKHEEAIHA VACHPSKALI ASAGADALAK VFV
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