About Tryptase gamma
Tryptase gamma (TPSG1) is a protein
from Homo sapiens identified by UniProt accession
Q9NRR2, 321 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Tryptase gamma |
|---|
| UniProt accession | Q9NRR2 |
|---|
| Gene | TPSG1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 321 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (47)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.32
- eosinophil count · score 0.12
- DNA methylation · score 0.10
- hypertension · score 0.10
- self reported educational attainment · score 0.10
- appendicular lean mass · score 0.08
- mathematical ability · score 0.07
- essential hypertension · score 0.07
- myeloid white cell count · score 0.07
- tryptase beta-2 measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NRR2-F1 | alphafold | PREDICTED | 82.39 | — |
Amino-acid sequence (321 residues)
MALGACGLLL LLAVPGVSLR TLQPGCGRPQ VSDAGGRIVG GHAAPAGAWP WQASLRLRRV HVCGGSLLSP QWVLTAAHCF SGSLNSSDYQ VHLGELEITL SPHFSTVRQI ILHSSPSGQP GTSGDIALVE LSVPVTLSSR ILPVCLPEAS DDFCPGIRCW VTGWGYTREG EPLPPPYSLR EVKVSVVDTE TCRRDYPGPG GSILQPDMLC ARGPGDACQD DSGGPLVCQV NGAWVQAGTV SWGEGCGRPN RPGVYTRVPA YVNWIRRHIT ASGGSESGYP RLPLLAGFFL PGLFLLLVSC VLLAKCLLHP SADGTPFPAP D
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