Glutaredoxin-2, mitochondrial (GLRX2)

About Glutaredoxin-2, mitochondrial

Glutaredoxin-2, mitochondrial (GLRX2) is a protein from Homo sapiens identified by UniProt accession Q9NS18, 164 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.

Target properties

Protein name	Glutaredoxin-2, mitochondrial
UniProt accession	Q9NS18
Gene	GLRX2
Organism	Homo sapiens
Length	164 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (68)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
Parkinson disease · score 0.28
Alzheimer disease · score 0.28
lysosomal storage disease · score 0.28
multiple sclerosis · score 0.28
neuroinflammatory disorder · score 0.19
chronotype measurement · score 0.12
lymphocyte count · score 0.11
Diuretic use measurement · score 0.09
lifestyle measurement · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NS18-F1	alphafold	PREDICTED	82.08	—

Amino-acid sequence (164 residues)

MIWRRAALAG TRLVWSRSGS AGWLDRAAGA AGAAAAAASG MESNTSSSLE NLATAPVNQI QETISDNCVV IFSKTSCSYC TMAKKLFHDM NVNYKVVELD LLEYGNQFQD ALYKMTGERT VPRIFVNGTF IGGATDTHRL HKEGKLLPLV HQCYLKKSKR KEFQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards