About Regulator of G-protein signaling 18
Regulator of G-protein signaling 18 (RGS18) is a protein
from Homo sapiens identified by UniProt accession
Q9NS28, 235 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Regulator of G-protein signaling 18 |
|---|
| UniProt accession | Q9NS28 |
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| Gene | RGS18 |
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| Organism | Homo sapiens |
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| Length | 235 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (86)
Diseases linked to this target (Open Targets).
- Abnormality of refraction · score 0.26
- metabolite measurement · score 0.10
- ovarian cancer · score 0.09
- protein measurement · score 0.09
- thrombocytopenia 7 · score 0.07
- bleeding disorder, platelet-type, 24 · score 0.06
- autosomal dominant macrothrombocytopenia · score 0.06
- platelet-type von Willebrand disease · score 0.06
- Glanzmann thrombasthenia 1 · score 0.06
- essential thrombocythemia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NS28-F1 | alphafold | PREDICTED | 72.39 | — |
Amino-acid sequence (235 residues)
METTLLFFSQ INMCESKEKT FFKLIHGSGK EETSKEAKIR AKEKRNRLSL LVQKPEFHED TRSSRSGHLA KETRVSPEEA VKWGESFDKL LSHRDGLEAF TRFLKTEFSE ENIEFWIACE DFKKSKGPQQ IHLKAKAIYE KFIQTDAPKE VNLDFHTKEV ITNSITQPTL HSFDAAQSRV YQLMEQDSYT RFLKSDIYLD LMEGRPQRPT NLRRRSRSFT CNEFQDVQSD VAIWL
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