CREB/ATF bZIP transcription factor (CREBZF)

About CREB/ATF bZIP transcription factor

CREB/ATF bZIP transcription factor (CREBZF) is a protein from Homo sapiens identified by UniProt accession Q9NS37, 354 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	CREB/ATF bZIP transcription factor
UniProt accession	Q9NS37
Gene	CREBZF
Organism	Homo sapiens
Length	354 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.40
PHF-tau measurement · score 0.09
neurofibrillary tangles measurement · score 0.09
breast cancer · score 0.07
Insulin resistance · score 0.07
insulin resistance · score 0.07
neoplasm · score 0.05
lean body mass · score 0.05
gonorrhea · score 0.04
joint damage measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NS37-F1	alphafold	PREDICTED	61.47	—

Amino-acid sequence (354 residues)

MRHSLTKLLA ASGSNSPTRS ESPEPAATCS LPSDLTRAAA GEEETAAAGS PGRKQQFGDE GELEAGRGSR GGVAVRAPSP EEMEEEAIAS LPGEETEDMD FLSGLELADL LDPRQPDWHL DPGLSSPGPL SSSGGGSDSG GLWRGDDDDE AAAAEMQRFS DLLQRLLNGI GGCSSSSDSG SAEKRRRKSP GGGGGGGSGN DNNQAATKSP RKAAAAAARL NRLKKKEYVM GLESRVRGLA AENQELRAEN RELGKRVQAL QEESRYLRAV LANETGLARL LSRLSGVGLR LTTSLFRDSP AGDHDYALPV GKQKQDLLEE DDSAGGVCLH VDKDKVSVEF CSACARKASS SLKM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards