Probable G-protein coupled receptor 173 (GPR173)

About Probable G-protein coupled receptor 173

Probable G-protein coupled receptor 173 (GPR173) is a protein from Homo sapiens identified by UniProt accession Q9NS66, 373 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	Probable G-protein coupled receptor 173
UniProt accession	Q9NS66
Gene	GPR173
Organism	Homo sapiens
Length	373 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

Neurofibromatosis type 6 · score 0.07
Dowling-Degos disease 1 · score 0.07
familial progressive hyperpigmentation · score 0.07
linear atrophoderma of Moulin · score 0.07
familial generalized lentiginosis · score 0.07
acroleukopathy, symmetric · score 0.07
dyschromatosis symmetrica hereditaria · score 0.06
Dyschromatosis universalis · score 0.06
attention deficit hyperactivity disorder · score 0.06
hyperpigmentation with or without hypopigmentation, familial progressive · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NS66-F1	alphafold	PREDICTED	81.28	—

Amino-acid sequence (373 residues)

MANTTGEPEE VSGALSPPSA SAYVKLVLLG LIMCVSLAGN AILSLLVLKE RALHKAPYYF LLDLCLADGI RSAVCFPFVL ASVRHGSSWT FSALSCKIVA FMAVLFCFHA AFMLFCISVT RYMAIAHHRF YAKRMTLWTC AAVICMAWTL SVAMAFPPVF DVGTYKFIRE EDQCIFEHRY FKANDTLGFM LMLAVLMAAT HAVYGKLLLF EYRHRKMKPV QMVPAISQNW TFHGPGATGQ AAANWIAGFG RGPMPPTLLG IRQNGHAASR RLLGMDEVKG EKQLGRMFYA ITLLFLLLWS PYIVACYWRV FVKACAVPHR YLATAVWMSF AQAAVNPIVC FLLNKDLKKC LRTHAPCWGT GGAPAPREPY CVM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards